| Date | Location | Result | |
| 4/23/2022 | Lynn University | Lynn 15, Saint Leo 12 | |
| 4/19/2022 | West Palm Beach | Saint Leo 12, Palm Beach Atl. 9 | |
| Apr 16, 2022 | St. Leo, FL | Rollins 11, Saint Leo 10 | |
| Apr 13, 2022 | St. Leo, FL | Tampa 22, Saint Leo 8 | |
| 4/9/2022 | Daytona Beach, Fla. | Embry-Riddle (FL) 17, Saint Leo 15 | |
| Apr 6, 2022 | St. Leo, FL | Fla Southern 18, Saint Leo 16 | |
| 3/26/2022 | MELBOURNE, FLA. | Florida Tech 19, Saint Leo 13 | |
| Mar 23, 2022 | St. Leo, FL | Saint Leo 19, WOLVES~1 12 | |
| Mar 20, 2022 | St. Leo, FL | FROST 18, Saint Leo 17 | |
| Mar 04, 2022 | Wilson, N.C. | Saint Leo 20, Barton 8 | |
| Mar 12, 2022 | St. Leo, FL | Saint Leo 22, FLG 13 | |
| Feb 20, 2022 | Saint Leo, Fla. | Saint Leo 16, UAH 14 | |
| Feb 18, 2022 | Saint Leo, Fla. | Saint Leo 19, Montevallo 11 | |
| 2/12/22 | Gaffney, S.C. | Limestone 17, Saint Leo 7 |